الفهرس | Only 14 pages are availabe for public view |
Abstract Flow cytometry is a modality with ever increasing applications in modern hematological, microbilogical and immunological fields. This is due to rapidity of obtaining results, ease of use and insreasing power to detect abnormal populations of cells. Recent advances in the availabilty and reproducibility of monoclonal antibody reagents specific for a wide range of of cell types coupled with lower costs for increasingly automated flow cytometers and user data analysis capabilities have made flow cytometry the method of choice for immunophenotyping in the clinical laboratory(Dunphy 2004). The use of flowcytometry in the clinical laboratory has grown substantially in the past decade, this is attriutable to the development of smaller, more user friendly, less expensive instruments and the continuous increase in the types of monoclonal antibodies.In hematology it can be used for Leukemia and Lymphoma phenotyping, identification of prognostically important subgroups, detection of minimal residual disease, multidrug resistance, in addition to diagnosis of paroxysmal nocturnal haeoglobinuria and systemic mastocytosis.In immunology it can be used for ctem cells enumeration, histocompatibility cross matching |