الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of this work is to evaluate the efficacy of breast conservation surgery plus radio-chemotherapy for early stage breast cancer patients, to determine mortality and recurrence rates and to evaluate prognostic factors for these outcomes. Loco regional recurrence was detected in 3 patients out of 50 (6%), 16, 21 and 36 months postoperatively. Distant metastases were detected in one patient to the liver after 18 months (2%). As regards the overall survival 2 patients out of 50 (4%) died because of one due to distant metastases to the liver and the other due to heart failure. As regards recurrence free survival 46 patients out of 50 (92%) had no problems for survival during follow up either because of local recurrence (3 patients) and distant spread (1 patient). As regards cosmotic results, 13 patients (26%) had excellent cosmetic results, 28 patients (56%) good and 9 patients (18%) fair results. Breast conservation therapy could be a suitable option for the Egyptian women with early breast cancer of stage 1 & 2, and from the previous results and owing to the satisfactory documented efficacy of radiation and chemotherapy to prevent or at least delay local recurrence and the fact that 95% of local recurrences in the breast are salvageable with no effect on survival, are encouraging factors although a longer follow up and a large number of patients are required for more accurate results, also a regular close follow up is recommended to detect any late relapse especially in the presence of high risk factors for local recurrence. |