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Abstract
Vitamin E deficiency is one of the most important causes of hemolysis as E is an antioxidant that acts to prevent destruction of un saturated fatty acid and cell membrane by uncontrolled free radicals. vitamin E is a potent free radicals scavenger. his study evaluated the effect of early adminstration of vitamin E on hyperbilirubinemia in preterm infants as erythrocytes of preterm infants have markedly shortened survivbal compared to Erythrocytes ofv term infants so play a contributory role in the development of hyperbilirubinemia in the early neonatal period. so vitamin E deficiency in preter infants increase the rate of red cell haemolysis and increase incidence of hyperbilirubinemia.