الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Diabetic retinopathy (DR) is one of the commonest and easily demonstrable examples of microvascular damage that diabetes inflicts throughout the body. DR is among the leading causes of blindness in people of working age, affecting both the genders equally.Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor that is strongly implicated in type 2<diabetes mellitus (T2DM) complications.While the pathogenesis of diabetic retinopathy is highly complex and not fully understood, VEGF is recognised as a major contributor to the development of diabetic retinopathy. Macular oedema, preretinal neovascularisation and neuronal degeneration are primary features of diabetic retinopathy, which result from breakdown of the blood retinal barrier (BRB), angiogenesis or neuronal apoptosis, respectively.The human VEGF gene is organized in eight exons, separated by seven introns and is localized on chromosome 6p21.3.The VEGF gene is highly polymorphic. Several studies have shown that polymorphisms in the promoter as well as in the 5 ׳ and 3 -׳
untranslated regions of the VEGF gene are associated with the production of the VEGF protein.This study was done to assess the possible relationship of two polymorphisms of VEGF gene (the 18 bp Ins/Del at -2549 of the promoter region and +405GC polymorphism in the 5′-untranslated region) with diabetic retinopathy in type 2 diabetic patients. This study was carried out on 75 individuals classified into three groups: 40 diabetics with retinopathy, 20 diabetics without retinopathy and 15healthy controls.Measurement of fasting blood glucose, glycated hemoglobin and genotyping for the two VEGF polymorphisms was undertaken for eachindividual.