الفهرس 
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Abstract
Recently, anti-obesity drugs have found wide use among large sectors of young, idd1e-aged as well as old patients. Accordingly, an increased use of drugs that treat type-2 diabetes mellitus has been noticed. The latter has represented the main disorder that associated the prevalence of obesity. Accordingly, it has deemed necessary to propose suitable and reasonable methods for the assay of these drugs in bulk and in their pharmaceutical preparations. Sucralose, the artificial sweetener, Sibutramine hydrochloride monohydrate, Rosiglitazone maleate as well as Metformin hydrochloride were selected for investigation in the present work.
Different methods have been used for their determination either in uni-dosage form or
in binary mixture. These methods include spectrophotometric [conventional (A method) and
derivative (D1 method)], spectrofluorimetric and chromatograpbic methods [HPTLC].
‘Sucralose, (SUC), is an artificial non-nutritive sweetener that has been widely used recently. Detection of SUC and other carbohydrates is really challenging because they lack a strong chromophore and, therefore, cannot be detected at low concentrations spectrophotometrically or chromatographically with UV detection. In the present work.