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Abstract SUMMARY One hundred and ten HCV-infected patients were included in this study. They had elevated liver enzymes, circulating anti-HCV antibodies and/or HCV-RNA viraemia. Moreover, they were seronegative for hepatitis B virus and Schistosoma infection. Fifteen subjects who had liver function tests within the normal range, no serological evidence of hepatitis B and C virus infection and were histopathologically-free from any hepatic lesions served as controls. Histologic assessment of liver sections from 110 HCV-infected patients showed features of chronic hepatitis C (CHC) in 50 specimens, liver cirrhosis (LC) in 30 specimens and hepatocellular carcinoma (HCC) in 30 biopsies. Assessment of liver sections with HCC revealed features consistent with well-differentiated tumors in |