الفهرس 
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Abstract
New chemotherapy druns are under development and evaluation all the time. These may be either riovel compounbs or, more commonly, derivatives of existing drugs which have been modified to alter certain characteristics (e.g. less renal toxicity, and vomiting associated with carboplatin compared with cisplatiTi). Iilhere possible, patients receiving new chemotherapy drugs es sinole ecents or in combination should b entered irito well structured clinical trials, deigned to evaluate their future role. In general, new chemothe— racy t.reatments should not be adopted into widespread ue without clearly documented evidence of efficacy in uch rndomized trials. (rahm Mead, 1987)
Fundamental advances coritinue to be made in th cnrnotherapy of’ neoplestic diseases. The greatat crre.3s in the last few years has been not in the di3covL2ry of large numbers of new useful chemotherape— utic agents but at the conceptual level the design of more effectivE regimens for concurrEnt adminstretion of rirugs, the acquisition of knowledge f the mechamism of action f many anti—tumor agents which facilitates the desirni of new methods to prevent or minimize drug toxicity; the increased use of adjuvant chemotherapy (e.g, the design of chemotherapeutic approaches to destroy inicrometastases and prevent the development of secondary neoplasms after removal or destruction of the primary tumor by surgery or irradiation).(Eoodii id Oilman, 1980)., and increased knowledge about such vital processes as tumor irritation and dissemination, implantation and growth of metastases. Of great importaice is the recognition of theproblenis imposed by the hetero— genecity of tumors with the realization that individual tumors may contain many subpopulations of neoplastic cells which differ in crucial characteristics such as karyotype, morphology, imrnunogenecity, rate of growth, the capacity to metastasize and signficantly, responsiveness to antineoplastic agents (Galabresi et al, 1979)..
Information also continue to accumulate •in the fields of molecular end cellular bioloqy resulting in a greater understanding of cellular biology, greater understanding of cellular division and differentiation, tumor immunolocy, and viral and chemical carcinogenesis. Particularly significant has been the continued evolution of effective technics for clinical investigatioi; this often involves large multi—institutional collaborative studies, whic.h have enabled the efficient evaluation and prompt introduction of new drugs or drug combinations into the clinic.