الفهرس | Only 14 pages are availabe for public view |
Abstract Sheep can be affected with a variety of central nervous system (CNS) diseases, including bacterial, protozoal, and viral infections; toxins; metabolic disturbances; trauma and neoplasia. Encephalitic listeriosis was more frequent in female (67.86%). Listeriosis and pregnancy toxemia appeared to affect mostly the age group above 12 months old (60.71%, 78.57%) respectively. Encephalitic listeriosis diseased sheep are depressed, moving in a circle towards the affected side, drooping ears, flaccid lips, and paralyzed check. Sheep with pregnancy toxemia show isolation from the flock, poor body condition, decreased flight response to approach, and decreased eye preservation and auditory reflexes. Isolation of Listeria monocytogenes were occurred from brain tissue after cold enrichment and CSF from living animals samples on blood and PALCM media and followed by microscopical and biochemical identification. Serum and CSF biochemical parameters in listeriosis and pregnancy toxemia show a higher significant increase in AST, CK activity, βHBA, creatinine, urea levels than control group but a higher significant decrease in glucose level than control group. In non responsive group there is a higher increase in level of AST, CK activity, βHBA, creatinine, urea than responsive group and a higher decrease in glucose value than responsive group. Serum and CSF oxidant and antioxidant biomarkers show a significant increase in H2O2 level in Listeriosis and pregnancy toxemia groups than control group with a significant increase in non responsive than responsive group. Also a significant decrease in Vit-C level in the both groups with a higher decrease in non responsive than responsive group. GPx and TAC values in Listeriosis show a higher significant elevation than control group with a higher significant increase in responsive than non responsive groups. Meanwhile, GPx and TAC value in pregnancy toxemia cases show a significant decrease than control group with a higher significant decrease in non responsive than responsive group. Trace elements in serum and CSF in listeriosis and pregnancy toxemia show a higher significant increase in copper and iron levels than control group with a higher elevation in non responsive than responsive group. Zinc results reveal a higher significant decrease in zinc level than control group with a higher significant increase in non responsive than responsive and control group. Serum and CSF immunological parameters in listeriosis and pregnancy toxemia show a higher significant increase in TNF-α, IL-12β, IL-6 than control group with a higher increase in non responsive than responsive group. IL-10 result show a higher significant increase than control group with a significant decrease in non responsive than responsive group. On the other hand, IL-10 show a higher significant decrease in pregnancy toxemia than control pregnant sheep with a higher significant decrease in non responsive than responsive group. |