الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Doxorubicin (DOX), an anthracycline antibiotic, is a broad-spectrum antineoplastic agent, which is commonly used in the treatment of uterine, ovarian, breast and lung cancers, Hodgkin’s disease and soft tissue sarcomas as well as in several other cancer types. The effect of doxorubicin intraperitoneal injection at dose level of 4 mg/kg b.w./week without or with oral administration of ethanolic purslane (Portulaca oleracea) shoot (leaves and stems) extract (50 mg/kg b.w./ day) or seed extract (50 mg/kg b.w.day) for 6 weeks was evaluated in adult male rats. Serum ALT, AST, ALP, GGT, CK-MB and LDH activities as well as total bilirubin, total protein, albumin, urea, uric acid, creatinine, testosterone, FSH and LH levels were assayed. Lipid peroxidation (indexed by MDA) and antioxidants of liver, kidney, heart and testis like glutathione content and glutathione transferase, peroxidase, SOD and CAT activities were assessed. In doxorubicin - administered rats, there was an increase in serum ALT, AST, ALP and GGT activities and total bilirubin concentration reflecting liver dysfunction as well as an increase in activities of CK-MB and LDH reflecting heart mal-function. The serum total protein, albumin and globulin levels were decreased. The serum testosterone, FSH and LH levels were lowered indication doxorubicin-induced sexual dysfunction while serum creatinine, urea and uric acid concentrations were increased reflecting kidney injury. With regards oxidative stress, glutathione content and glutathione-S-transferase, peroxidase, SOD and CAT activities were decreased while lipid peroxidation was increased in liver, kidney, heart and testis. Co-administration of ethanolic purslane and seed extracts successfully improved the adverse changes in liver, kidney, heart and testis functions with an increase in antioxidants activities and reduction of lipid peroxidation. In coclusion, it can be supposed that dietary purslane extract supplementation may provide a cushion for a prolonged therapeutic option against DOX toxicity without harmful side effects. However, further clinical studies are required to assess the safety and efficacy of these extract in human beings.