الفهرس 
EXPERIMENTAL PARTOnly 14 pages are availabe for public view
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Abstract
Intoxication with centrally active anticholinergic agents occurs in a
number of clinical settings. Perhaps the most common IS the
unanticipated reaction In sensitive individuals to preanaesthctic
medication with atropine or scopolamine. Otherwise anticholinergic
intoxication JS encountered with appreciable frequency in patients with
extrapyramidal disorders who are treated with the antiparkinsonian
atropine-like drugs. Reactions may also occur following the instillation of
solutions of anticholinergic drugs in the conjunctiva to produce mydriasis.
In addition to the anticholinergic drugs proper, a large number of other
drugs such as the antihistaminics, hypnotics, antidepressants and
tranquillizers possess significant central anticholinergic activity (Duvoisin
et al., 1968; Friedman, 1980 ).
The various drugs incriminated have been reviewed by Longo in
(1966), who has originally coined the term ”Central Anticholinergic
Syndrome” for the central nervous system (CNS) manifestations of
toxicity by these drugs. The syndrome consists of confusion, agitation,
hallucinations, dysarthria, ataxia, delirium, speech disturbances, stupor
and even coma which may persist for up to% hours. The syndrome may
also be accompanied with certain peripheral anticholinergic manifestations
such as tachycardia, hyperpyrexia, mydriasis. vasodilatation.
unnary retention, reduced gastrointestinal motility and decreased
secretions of salivary and sweat glands. The nasal, pharyngeal, and
bronchial secretions arc also much reduced (Holzgrafc eta/., 1973). It is to
be noted that some of the above mentioned drugs such as the tricyclic