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Abstract What is the relationship between plant parts used in nutrition and its relationship with some related diseases gland liver to need the further study and clarification as well as accounted disease of continues to paint the liver, a large proportion in most of the world’s population, but rather, we find that those who suffer from obesity around the world must become infected degree of grades FLD a problem is also widespread in Egypt as a result of the consumption of large amounts of fatty substances and sugary uncontrolled , these it all paid to study root of the plant ginger including contents of active substances to track and study its effect of fatty liver which obtained the rhizomes ginger which purchased from impact the local market , and divided into two parts owing to obtaine the aqueous and alcohol extracts to determine the organic compounds and phenolic as well as chemical the constituents ginger of rhizomes which to slices and immersed in 1 liter of alcohol 95% ethanol with vibration intermittent for 24 hours and then heated for 3 hours under the pressure of 45 m to vaporize the nomination. Aqueous extracts also were cutting (1 kg of ginger rhizomes) into slices and immersed in 1 liter of distilled water with intermittent vibration for 24 hours and then heated for 3 hours under the pressure of 45 m to vaporize the nomination. Thirty six female albino rats white-type Sprague Dawley were fed on a standard diet for six days before the beginning of the experiment, in order to adapt. Experiment was design as rat divided into 6 groups, consists of six rats as follows: A- Control group: first: Experiment was design as a group and negative control group and fed on the basic length of the experiment of the meal. B. Group B: Experiment was design as group and positive control group which fatty for infected liver which fed on 10% of fructose. C. Group C: and are fed on Fructose 10% , in addition to the injecte with gastric tube mouth infectious of at with aqueous extract of ginger rhizomes (50 mg / kg). D- Group D: fed on Fructose at rate of 10%, in addition to the injected with gastric tube mouth infectious with alcoholic extract of ginger rhizomes at the rate of (50 mg / kg). E. Group E: Injected with aqueous extract of ginger rhizomes at a rate of (50 mg / kg). F. Group f: Injected with alcoholic extract of ginger rhizomes at the rate of (50 mg / kg) and continues to experiment a period of 5 weeks. At the end of the experiment , Bio-biological assessment was determine of the different meals as percentage of weight gain, feed efficiency ratio was accounted, where there was a consensus between the consumption of feed and significantly increased the body weight and in the groups which contain a high concentration rate. The impact rhizomes of ginger extracts on weight gain and feed efficiency ratio for the control group recorded a slight increase in weight as a result of eating a meal free of material treatment, while other groups have seen a very high rise in the weights owing the continuous increase throughout the period of the experiment. With respect to the final weight , control positive has seen the highest values and show sixth group with less values. As for weight of the members may have seen (the small intestine - kidney- spleen) with higher values for the rest of the members. Also biochemical study on, which is meant to study the psychology of enzymatic were estimated the enzymes which indicated the response of the liver to do as a result of the impact of dealing with ginger extracts. Supported this study blood, where examination estimated the number of red and white blood cells, as well as the percentage of Haemoglobin, and platelet count as a whole blood where one of the categorical evidence of the effect extracts under this study, on the general vitality and the immune system as well as the mechanism of clotting and the incidence of infections, which gives the possibility to judge on the use of extracts from the place or not. Biochemical study was done to estimate the ratio of blood lipids, including triglycerides, total cholesterol, which is an important factor to judge the effectiveness of the extracts under this study. Histopathological study was done to determine the exact status of liver tissue, kidney and spleen, eyes, brain, lungs, heart and intestines to promote the study on biochemical reaction extracts under this study on the body. Obtained the blood samples: at the end of the experiment, feeding was preventing food from the rats for 12 hours and then drugged using Dai ethyl ether was obtained blood samples from the hepatic portal vein in a clean, dry and store centrifuges at room temperature for 15 minutes tubes. It was the work of centrifuges (4000 rpm / 10 minutes at room temperature) sera were separated and transferred and stored in a (20 °) until analyzed. It was performed biochemical analyzes of blood samples and samples of serum for a complete blood picture, and estimate the sedimentation velocity in the blood, and estimate the insulin in the blood, and the percentage of fat in the blood, and indicators of liver function, and estimate the proportion of fat in the tissues of the liver. Members were extracted (liver, kidney, heart, lungs, spleen, brain eyes, the small intestine) and washed in brine and weight and then save them in formalin solution (10%). The check histopathological samples (liver, kidney, heart, lungs, spleen, brain eyes, the small intestine). Statistical analysis was also through compact using Microsoft Office and Windows computers. Using SAS software was also used SPSS software to compare the groups treated with the study, and all the results that have been obtained have been tabulated and make appropriate recommendations. The following results of this study: Feed studies and physical measurements of experimental animals-1 1. When comparing the weights between the Group (negative + Group that are injected with 10% fructose) as well as showed that the highest percentage increase in weight was in favor of the group that are injected with 10% fructose Ameliorates followed by negative group. 2. When comparing the weights between the Group (the Group that were injected with 10% fructose as well as 50 mg of aqueous extract of ginger + Group that are injected with 10% fructose and 50 mg of the alcoholic extract of ginger) and showed that the highest percentage increase in weight was in favor of the group that injected with aqueous extract of ginger. 3. When comparing the weights between the Group (the Group that are injected with 50 mg of aqueous extract of ginger + Group that are injected with 50 mg of the alcoholic extract of ginger) and showed that the highest percentage increase in weight was in favor of the group that injected aqueous extract of ginger. 4. When examining the rates of consumption of food among all groups: it was observed that feed consumption rate was in favor of the group (injected with 10% fructose +50 mg of the alcoholic extract of the rhizomes of ginger), followed by group (injected with 10% fructose +50 mg of aqueous extract the rhizomes of ginger), followed by group (injected with 50 mg of aqueous extract of the rhizomes of ginger), followed by group (injected with 50 mg of the alcoholic extract of the rhizomes of ginger), followed by group (injected with 10% Ameliorates fructose), while it was lowest ratio of feed consumption for the group (negative control). 5. When examining the effect of extracts under study on the liver weight turns out that the highest weight was in favor of the group (injected with 10% fructose) at all while was got a group (injected with 10% fructose +50 mg aqueous extract) on the second arrangement, The less weight of the liver is located in the group (injected with 10% fructose +50 mg of alcoholic extract of ginger rhizomes). 6. Noted that less weight to the total weight is in the group (negative control), while the highest weight at all was for the benefit of (that are injected with 10% fructose), followed by group (injected with 10% fructose +50 mg aqueous extract). 7. It turned out that the highest spleen weight was in favor of the group (injected with 10% Ameliorates fructose +50 mg of the alcoholic extract of the rhizomes of ginger) as well as less weight of the spleen is located in the group (injected with 50 mg of the alcoholic extract of the rhizomes of ginger). 8. It was also noted in the eye that the weight of the highest weight at all Group (negative control) as well as less weight to the eye is located in the group (injected with 10% fructose +50 mg aqueous extract). 9. It was also found that less weight to the weight of the brain is located in the group (injected with 10% fructose +50 mg aqueous extract) and the highest weight was in favor of the group (negative control). 10. It was also noted in the intestines Weight minute that the highest weight on the launch group (injected with 10% fructose) as well as less weight minute in the group of the gut (that are injected with 10%Ameliorates fructose +50 mg of alcoholic extract of ginger rhizomes). Biochemical studies The effect of ginger extracts on the indicators biochemical (blood picture full - the level of insulin in the blood - erythrocyte sedimentation rate - the liver enzyme GOT - cholesterol and triglycerides in the serum). |