الفهرس | Only 14 pages are availabe for public view |
Abstract This work aims to synthesize some peptides derivatives having quinazoline moiety to study their biological activity. Thus, Peptide bond was prepared from quinazoline via reaction of quinazoline derivatives 1 and 2, K2CO3, dry acetone, with ethyl chloroacetate afforded 3 and 4 in 68-72% yields, followed by treatment with hydrazine hydrate to yield 5 and 6 in 85-87% yields, respectively. A solution of 5 and 6 in AcOH, 1N HCl, and H2O was cooled then treated with a solution of the appropriate amino acid ethyl ester hydrochloride in ethyl acetate to afford 7a,b and 8a,b in 75–80% yields. |