الفهرس | Only 14 pages are availabe for public view |
Abstract Spleen represents the meeting point between antigenic information transported by blood stream and immune apparatus responsi ble for mounting the host response ( Lokwood, 1983). The spleen makes up to 25% of the total lymphoid mass and is an important component of the reticu loendothelial system (Ellison et al., 1983 ) . Aim of the work Is to study the immune profi le in patients with chronic liver disease and portal hypertension after total splenectomy Patients and Methods In this study, ten patients with portal hypertension were subjected to elective splenectomy. Haematological profile and imm unological profile (lgM, IgG, lgA, CD4, CDS, CD19, CD3, and CD4/CD8) was done before and one month after splenectmy. Immunological profile for ten normal control was measured . Results Splenectomy in portal hypertension improve all blood elements counts but decrease patient cellular immunity in form of decrease total T lymphocyte, T helper and increase T suppressor and decrease ratio . |