الفهرس | Only 14 pages are availabe for public view |
Abstract Recurrent skin abscesses is a leading cause for transferal to immunologists, while most of these patients have normal immunity and with no underlying primary immune deficiency disease. Neutrophils is the most abundant cell in WBCs and the first cell to encounter bacteria and infections. Primary phagocytic cell defects account for 10 to 15% of primary immunodeficiency’s. Cutaneous infections are characteristic. One of the Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 update by the Infectious Diseases Society of America recommends for recurrent skin abscesses is that Adult patients should be evaluated for neutrophil disorders especially if abscesses began in early childhood. In our study we found significant relation between neutrophil phagocytic cell dysfunction and recurrent skin abscesses in age group from 18 to 42. The more extended the organ involvement, the greater the chance for finding a phagocytic impairment. Establishing early diagnosis and offering appropriate treatment and genetic counseling for these patients and their families are essential to prevent premature mortality and the damage inflicted by chronic infection. |