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Abstract 40 young regularly menstruating girls with type 1 diabetes mellitus were recruited from the Paediatric Diabetes Clinic, Children’s hospital, Ain Shams University in the interval from April, 2015 to November, 2015. Their age ranged 11.54 - 17.93 years with mean age 15.44 years. All patients were subjected to a detailed medical history, physical examination, anthropometric measurments, pubertal assessment, investigation from previous follow up records (last RBS, last FBS, mean FBS in the last 6 months, last HbA1C, mean annual HbA1C and microalbuminuria), and measurements of IVS1-397T>C estrogen receptor alpha genotypes, FSH and LH |