الفهرس 
Vitamin D Physiology
Cardiovascular healthOnly 14 pages are availabe for public view
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Abstract
Vitamin D inadequacy and deficiency are global problems .Low maternal vitamin D levels during pregnancy have been associated with multiple adverse neonatal outcomes, including small for gestational age, effects on offspring bone, and risk of infectious diseases. Vitamin D has been linked with immunity, and the immunomodulatory role of this molecule in regulating key elements of the immune system has become an area of intense scientific investigation.
Objective:
1) To assess maternal vitamin D status and its impact on neonatal cord blood vitamin D levels
2) To correlate any associations between neonatal levels of vitamin D based on cord blood samples and
A. Neonatal outcomes such as infant weight, infant length, infant head circumference, and Apgar score.
B. The subsequent risk of neonatal sepsis.
Study Design:
A cross-sectional study was carried out at Nasr city insurance hospital in Cairo, Egypt. Serum 25(OH) D levels were measured by enzyme-linked immunosorbent assay in 35 pregnant women at > 36 weeks’ gestation 24 hours pre-delivery and in cord blood of their newborns, anthropmrtric measurement was taken just after delivery and Blood was drawn during the first 5 postnatal days of life to evaluate hematological scoring of sepsis.
Result:
A positive correlation was detected between maternal and neonatal 25-OHD levels. Severe vitamin D deficiency was significantly more common in multipara, non educated low socioeconomic level women living in urban area . significant positive correlation was found between cord blood vitamin D level and birth weight ,birth length Apgar score and subsequent risk of early onset neonatal sepsis.
CONCLUSIONS:
Maternal vitamin D levels strongly correlate with neonatal levels, and neonatal vitamin D deficiency is generally related to low maternal educational level, socioeconomic state ,residency ,parity and high pre pregnancy BMI and there was a significant correlation between vitamin D deficiency and neonatal anthropometric measurement and neonatal health state at birth.
KEYWORDS:
Vitamin D deficiency; pregnancy; anthropometric measurement; Apgar score; early onset neonatal sepsis.