الفهرس | Only 14 pages are availabe for public view |
Abstract Peripheral neuropathy is a general term that indicates any disorder of the peripheral nervous system. Guillain – Barré syndrome consider one of the most important cases of peripheral neuropathy is GBS. The cornerstone in diagnosis of peripheral neuropathy is electrophysiological assessment of peripheral nerves which includes 2 major components, nerve conduction study and needle electromyography. Since the marked decline in poliomyelitis incidence, the GB syndrome is now the most common cause of acute flaccid paralysis in many countries. Guillain–Barré syndrome occurs in all age groups, although rarely in infants, and the incidence varies. from birth to 30 years, the annual incidence is fairly uniform at 1.3 to 1.9 per 100.000. Peaks are noted in late adolescence and young adulthood, as well as in the elderly. The first peak likely correlates with increased risk of cytomegalovirus and Campylobacter jejuni infection. The reason for the peak in the elderly is unknown but is postulated to be caused by failing immune suppressor mechanisms. Two thirds of people with GBS have experienced an infection before the onset of the condition, most commonly these are episodes of gastroenteritis or a respiratory tract infection. The nerve dysfunction in GBS is caused by an immune attack on the nerve cells of the peripheral nervous system and their support structures. |