الفهرس 
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Abstract
The CD20 positivity initiate signals involving tyrosine kinase activation .The time of remission of ALL studying group is non-significance because the effect of abnormalities of t (9, 22) activate tyrosine kinase by inhibiting the effect of chemotherapy and increase resistance of blast cells so, CD20 positive expression in childhood B-Cell Precursor Acute Lymphoblastic leukemia (BCP-ALL) had bad clinical impact. Stratification of children with (BCP-ALL) according CD20 expression and Philadelphia chromosome into four subgroups. The combined positivity for CD20 and Ph chromosome groups had poorest overall survival and shortest disease free survival. from our study we can recommended that the inhibitor of tyrosine kinase has integrated into the treatment regimens for pediatric Philadelphia chromosome positive ALL and also we can incorporate CD20 targeted monoclonal therapy would result in a clinical benefit as reported in adult studies by the effect of anti CD20 as apoptosis of the blast cells.