الفهرس | Only 14 pages are availabe for public view |
Abstract Androgenetic alopecia (AGA) is hair loss that occurs due to an underlying genetic susceptibility of hair follicles to androgenic miniaturization. It is the most common cause of hair loss affecting up to 70% of men and 40% of women at some point in their lifetime with significant negative impact on their social and psychological well-being. Both genetic and environmental factors play a role, and many etiologies remain unknown. Serum homocysteine (SH) is one of the newer risk factors of CHD. It is a sulfur amino acid that is degraded in the transsulfuration pathway to cystathionine, a step that is catalyzed by cystathionine β-synthase. Alternatively, it can be remethylated to methionine via a pathway regulated by 5, 10-methylenetetrahydrofolate reductase (MTHFR). MTHFR converts 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the primary circulatory form of folate. In both pathways major genetic defects that cause enzyme deficiencies are associated with very high SH levels and excretion of homocystine into the urine. In conclusion Serum homocysteine level is higher than normal in AGA cases.There is positive correlation between serum HCY level and systolic blood pressure.MTHFR Gene polymorphism in 56.6% of AGA cases regarding CT genotype and 13.2% of AGA cases regarding TT genotype. |