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Abstract VKC is a bilateral, allergic inflammation of the conjunctiva, affecting predominantly boys in warm climates. The distribution of the main clinical hallmarks, upper tarsal giant conjunctival papillae and gelatinous limbal hypertrophy, varies considerably with different climatic conditions and races. Clinical and immunohistochemical studies suggest that IgEdependent and IgE-independent mechanisms are both involved in its immunopathogenesis, in which various inflammatory cells, including different T cell subpopulations play an active role. Although endocrine, genetic, neurogenic, environmental and socioeconomic factors have been identified, its aetiology remains unknown. Despite new insights in the mechanisms of ocular allergy, topical steroidal and non-steroidal immune modulators. The use of supratarsal injection of triamcinolone acetonide depot in refractory VKC cases has shown dramatic results. The procedure is usually well tolerated even in young children; it provides prompt symptomatic relief in all patients and has low recurrence rate (12.0%). The high rate of clinical response with lack of complication and yet easy method leads us to suggest that these therapeutic modality is an effective and safe method for treatment of refractory VKC and improve quality of life. |