الفهرس 
Epidemiology, classification and pathogenesisOnly 14 pages are availabe for public view
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Abstract
Introduction: Glomerulonephritis (GN), is a mass term used for a substantial number of diseases with the common denominator of histological renal inflammation emerging from the glomerular tuft, it is the second most common cause of chronic renal failure. GN is a major cause of morbidity and mortality from renal disease in many parts of the world, particularly in the tropical and sub¬tropical regions. According to several local registries and sporadic publications, it is responsible for about23.2 to 58.4% of patients on regular dialysis in the tropics, compared to contemporary areas of around 16-18% in the United States and 9-15% in Europe. It is responsible for 16.6%which has been reported in 1998 in Egypt.
Aim of the Work: To study the Histologic spectrum of glomerular diseases among Egyptian patients in Ain Shams university hospitals for a period of 3 years from 2011 to 2013 with its correlation with the clinical and laboratory parameters (Single center).
Subjects and Methods: A cross sectional retrospective study was done in pathology lab and EM lab of Ain Shams University specialized Hospitals referral center from different governorates in Egypt. We studied all clinical cases with glomerular diseases diagnosed with renal biopsies over a period of 3 years from 2011 to 2013.The study included 857 renal biopsies evaluated by LM, EM, IF.
Results: This is a retrospective study aimed at data collection in three years from 2011 to 2013 in Ain Shams university hospitals. The study included 857 renal biopsies, cases 2011: 163 (19%), 2012: 349 (40.7%) and 2013:345 (40.3%) with mean of age 31.35±18.43 years and range (3-81) years. Children <16 years: 241 (28.3%), adults (17-60years): 548 (64.2%), elderly >60 years: 64 (7.5%). 386 (45%) of total cases were females and 471 (55%) were males, co morbidities as hypertension in (22.9%) of cases followed by DM (5.6%) of studied cases.
We recorded that 196 patients were presented by hypertension and the most common pathological diagnosis associated with HTN is FSGS in (18.4 %) followed by membranoproliferative glomerulonephritis in (16.8 %): The most common pathological diagnosis in nephrotic syndrome is minimal change disease followed by membranous glomerulonephritis; In asymptomatic proteinuria is lupus nephritis followed by membranous glomerulonephritis; In CKD is FSGS followed by global glomerulo-sclerosis ; In hematuria is IGA followed by Alport syndrome; In nephritic is membranoproliferative followed by FSGS; In RPGN in crescentic followed by lupus nephritis; AKI in lupus nephritis followed by membrano-proliferative; Nephrotic nephritic in diffuse proliferative followed by membranoproliferative.
Keywords: FSGS: Focal segmental glomerulosclerosis; GN: Glomerulonephritis; MPGN: Membranoproliferative glomerulonephritis