الفهرس | Only 14 pages are availabe for public view |
Abstract The present work suggests different spectrophotometric methods for the determination of some antihypertensive drugs such as irbesartan, losartan, bis oprolol and hydrochlorothiazide which are used for tr eatment high blood pressure and prevent in g the pr oblems of hypertension, such as stroke and myocardial infraction. These methods provide simple, sensitive and inexpensive analytical procedures for estimation of the pure drugs and pharmaceutical formulations without interference from common excipients. RP - HPLC method was also one o f the tools of this study. This method was concerned with simultaneous separation and determination of mixture of atenolol, losartan and candesartan in their pure forms and the method was applied for determination of these compounds in presence of degradation products of candesartan . The plan of the work comprises application of the proposed methods on drug products, validation of the methods and statistical comparison with the reported or reference methods. |