الفهرس 
POLYCYSTIC OVARY SYNDROME (PCOS)Only 14 pages are availabe for public view
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Abstract
Polycystic ovary syndrome, is an important metabolic and reproductive disorder and is likely multifactorial in origin. Insulin resistance is important in the pathogenesis of PCOS, but the exact mechanisms of PCOS are unknown.
The current study was conducted in the gynecology and infertility clinics of Ain Shams University Maternity Hospital in the period between December 2016 and May 2017.
The aim of this study is to assess the association between adipokines and insulin resistance in women with PCOS.
In our study, serum adipokines were measured in three hundred patients with PCOS together with assessment of insulin resistance via HOMA2-IR. Stratification of study population into two subgroups according to quantified insulin resistance, followed by comparison of adipokine levels between both subgroups were done. Another stratification was done according to BMI and followed also by comparison of adipokine levels.
Comparison of adipokine levels in the elevated HOMA2-IR subgroup and the normal HOMA2-IR subgroup revealed absence of significant differences between the women of both subgroups regarding levels of adiponectin (0.33 ± 0.27 vs 0.38 ± 0.24, p= 0.41), gehrlin (1148.28 ± 1631.90 vs 581.5 ± 918.25, p=0.06 and resistin (612.28 ± 1053.71 vs 1012.92 ± 1393.52, p=0.17) respectively.
Negative correlation between HOMA2-IR and resistin levels was found (r= -0.24, p= 0.03), however, no statistically significant correlation was found between HOMA2-IR and adiponectin, gehrlin.
Comparison of adipokine levels in the lean subgroup and the overweight & obese subgroup revealed significant positive correlation between BMI and adiponectin levels (r =0.73, p <0.001) and negative correlation between BMI and resistin (r = -0.46, p <0.001); whereas other adipokines showed no correlation with BMI.
It might seem from our results that the obesity-adipokine imbalance association outweighs that between insulin resistance and adipokine imbalance. However, on careful analysis with previous studies with the same results in the literature and others with conflicting results, the multifactorial interdependent nature of the various elements implicated in the pathogenesis of PCOS seems to be evident. This is superimposed by the unpredictable limitations of the various assessment methods due to our limited knowledge of the molecular pathogenesis of PCOS.
Our study adds evidence to the association between Obesiy and adipokine imbalance in PCOS women. Treatment of obesity might be most beneficial to restore adipokine balance and avoid the complications of the metabolic syndrome.