الفهرس 
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Abstract
Purpose: The aim of this study was to determine the effect of non surgical periodontal treatment on GCF level of adrenomedullin (ADM) and interleukin 1 βeta (IL-1β) in patients with the moderate chronic periodontitis. Subjects and Methods : A total of thirty subjects was included in this study; 15 subjects with moderate chronic periodontitis (group I) and 15 systemically healthy subjects with clinically healthy gingiva as a control group (group II). The nonsurgical periodontal therapy was done to group I. Periodontal parameters, including Plaque index (PI), Gingival index (GI), bleeding on probing (BOP), Periodontal probing depth (PPD) and the Clinical attachment level (CAL), in all the sites were recorded. GCF samples were collected from all individuals included in the study; the first sample was collected from all groups (study and control) at the start of study. The second sample was collected 4 weeks after phase I therapy from group I. GCF levels of IL-1β and adrenomedullin were quantified using ELISA. Results: At the baseline the level of IL-1β and ADM in gingival crevicular fluid was significantly higher in chronic periodontitis patients than in healthy subjects. The results of the present study, showed a significant reduction in all clinical parameters (GI, PI, PPD, BOP and CAL) after phase I periodontal therapy in chronic periodontitis group. Level of IL-1β and ADM in gingival crevicular fluid were reduction significantly after a phase I periodontal therapy in moderate chronic periodontitis group when compared to their levels at baseline.Conclusion : ADM is present in GCF in periodontal health and disease, where its level is higher in moderate chronic periodontitis. Level of ADM in GCF could be considered as a novel biomarker in moderate chronic periodontitis.