الفهرس | Only 14 pages are availabe for public view |
Abstract Summary and Conclusion Major cardiac complications after cardiac surgery can substantially affect outcome (Smith RC et al. 1991). Early diagnosis and risk stratification are therefore important issues to develop therapeutic goals that could improve patient care. Therefore, reliable biologic markers as predictors of the occurrence of short and long term cardiac complications would be helpful in routine clinical practice (Jaffe AS et al. 2000). The B-type natriuretic peptide (BNP) is a neurohormone mainly secreted from cardiac ventricles by increasing ventricular wall stress and volume expansion (Hunt PJ et al. 1997). In response to the appropriate stimulus, BNP is finally cleaved into BNP and NT-proBNP which is more stable that makes its measurement more reliable (Hunt PJ et al. 1997). The objectives of this work were to find out the prognostic value of NT-proBNP as a valuable marker in predicting postoperative myocardial insult, short term outcome in patients undergoing open heart and evaluate the independency of this biomarker. Thirty five patients who had cardiac surgery in our department were enrolled in this study their ages ranged from 22 to 68 years, and they were 14 males and 21 females. Written informed consent was obtained from all patients included in the study. The study was approved by the Ethics Committee of Faculty of Medicine, Tanta University. |