الفهرس 
Introduction and aim of workOnly 14 pages are availabe for public view
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Abstract
Childhood pneumonia is an important cause of morbidity mortality in children. Community-acquired pneumonia is one of the most common serious infections in children, with an annual incidence of 34 to 40 cases per 1,000 children. Hospital-acquired or nosocomial pneumonia is the second-most-common nosocomial infection and is usually bacterial in origin.
Copeptin is the C-terminal part of pro- arginine vasopressin (AVP) and is released together with AVP during processing of the precursor peptide. Copeptin appears to be superior to cortisol in determination of the stress level.
The aim of the present study was to investigate the serum levels of copeptin and serum level of sodium in a group of hospitalized children with pneumonia, compare them to a matched healthy group of controls, and study relation of copeptin and sodium to other clinical and laboratory parameters of pneumonia.
This study included 80 child. Who attended El- Minia University maternal and childhood of El- Minia university.
They recruited during the period from January to December 2016. They were classified into 2 group.
group I children with clinical & lab evidence of pneumonia with age less than 5 years, 27 male and 13 female.
group II apparently healthy control who attended for non chest problem or serious medical condition
• All cases were subjected to a complete clinical study (thorough history and physical examination) upon study inclusion, with emphasis on symptoms and signs of pneumonia.
The following investigations were performed: complete blood counts (CBC), quantitative C-reactive protein (CRP), serum sodium level (Na), arterial blood gases (ABG) and serum copeptin by a commercial enzyme linked immunosorbent assay (ELISA) kit (WKEA MED SUPPLIES catalog. No WH-1768)k, Copeptin serum levels are significantly higher in pneumonic children compared to healthy controls.
Copeptin serum levels are significantly higher in non-survivor pneumonic children compared to survivors.
Copeptin is more prognostic than diagnostic marker in pediatric pneumonia
Sodium serum levels are significantly lower in pneumonic children compared to healthy controls.
Sodium serum levels are significantly lower in non-survivor pneumonic children compared to healthy controls.
There is no linear relationship between the sodium and copeptin levels, although the previously expected copeptin-sodium reverse correlation may be observed, particularly in patients without sodium disorders.