الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Traumatic brain injury (TBI) is a severe condition and a major cause of death and disability. TBI enhances pro-inflammatory responses and neuronal loss and results in significant disability due to cognitive deficits particularly in attention, learning, memory and locomotor activity. Aim: The present experimental study was designed to assess the effect of combination treatment of curcumin and candesartan on TBI in mice. Methods: Mice were classified into six groups (Sham, TBI, TBI given the vehicle, TBI treated by curcumin, TBI treated by candesartan and TBI treated by curcumin and candesartan), n=12 each. Mice were anesthetized and then placed under a weight-DROP device. The animals were killed by cervical dislocation, brains were rapidly isolated and homogenized. Results: TBI group exhibited significant increment in MDA, PGE2, TNF-Alpha, IL1-Beta, caspase -3, NF-κB, iNOS as compared to sham group and these effects were significantly ameliorated by curcumin, candesartan and their combination treatment. Also, short and long term memory, locomotor activity, TAC, SOD, BCL-2 decreased markedly in the TBI group and increased significantly by concurrent treatment with curcumin or candesartan. Furthermore, histopathological examination confirmed these findings. Conclusion: Collectively these findings indicate that curcumin and candesartan have potential anti-inflammatory, antiapoptotic and antioxidant effects beside their neuroprotective effect confirmed by the enhanced memory and locomotor activity. Accordingly, curcumin or candesartan might be employed as a therapeutic agent for TBI and the combined drug regimen succeeded in adding better effects than the individual drugs. Keywords: Curcumin, Candesartan, Traumatic brain injury, Antioxidant, Neuroprotective, Antiapoptotic, Anti-inflammatory. |