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Abstract Derivatives of 1-phenyl-2-amino-3-cyano-5-aryl-1H-pyrrole 4a-d were synthesized by the reaction of phenacylmalononitrile derivatives 3a-d with aniline in presence of conc HCl and ethanol under reflux1. Then, the derivatives of 1-phenyl-2-amino-3-cyano-5-aryl-1H-pyrrole 4a-d were refluxed with (85%) formic acid for 4h to afford derivatives of 6-aryl-7- phenyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 5a-d through the amide intermediate (Scheme 1). |