الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of this study was to demonstrate the possible role of EA on glycemic state and vascular reactivity in diabetic rats. Sixty male albino rat of local strain, weighing (200-250) grams each were used in this work. The animals were classified into the following groups: (I) Non diabetic group (II) Diabetic non treated group (III) Diabetic insulin treated group (IV) Diabetic (EA) treated group (V) Diabetic insulin and (EA) treated group At the end of experiment (8 weeks) each group was subjected to the following parameters 1. Laboratory testes: fasting serum level, insulin level, glycosylated hemoglobin, C peptide, malondialdehyde and total antioxidant capacity 2. Measurement of arterial blood pressure and in vivo vascular reactivity 3. Removal of the liver for estimation the rate of hepatic glycogenesis 4. Removal of the kidneys for estimation the rate of renal gluconeogenesis The results of this study showed that induction of diabetes mellitus by streptozotocin was associated with significant increase of fasting serum glucose, glycosylated hemoglobin, malondialdehyde, renal gluconeogenesis, arterial blood pressure and significant decrease of insulin level, C peptide, total antioxidant capacity, hepatic glycogenesis and vascular reactivity to all doses of vasoconstrictors and vasodilators, when compared with the corresponding values in the diabetic non treated group In the present work, insulin treatment resulted in significant decrease of fasting serum glucose, glycosylated hemoglobin, malondialdehyde, renal gluconeogenesis, arterial blood pressure and significant increase of insulin level, C peptide, total antioxidant capacity, hepatic glycogenesis and vascular reactivity to all doses of vasoconstrictors and vasodilators, when compared with the corresponding values in the diabetic non treated group. In the present study, EA therapy resulted in significant decrease of fasting serum glucose, glycosylated hemoglobin, malondialdehyde, renal gluconeogenesis, arterial blood pressure and significant increase of insulin level, C peptide, total antioxidant capacity, hepatic glycogenesis and vascular reactivity to all doses of vasoconstrictors and vasodilators, when compared with the corresponding values in the diabetic non treated group. In diabetic combined insulin and EA treated, there were significant decrease of fasting serum glucose, glycosylated hemoglobin, malondialdehyde, renal gluconeogenesis, arterial blood pressure and significant increase of insulin level, C peptide, total antioxidant capacity, hepatic glycogenesis and vascular reactivity to all doses vasoconstrictors and vasodilators, when compared with the corresponding values in the diabetic non treated group and insignificant when compared with the corresponding values in the control group. |