الفهرس | Only 14 pages are availabe for public view |
Abstract Cirrhosis is an advanced stage of liver fibrosis that is accompanied by distortion of the hepatic vasculature (Schuppan and Afdhal, 2008). Liver fibrosis results from chronic damage to the liver in conjunction with the accumulation of extra cellular matrix (ECM) proteins, which is a characteristic of most types of chronic liver diseases (Friedman, 2003). Cirrhotic liver is often the background from which hepatocellular carcinoma (HCC) and hepatocytic nodular lesions arise. Considering that more than 90% of hepatocellular carcinomas occur in cirrhotic livers so cirrhosis considers the main risk factor for HCC (Muller, 2006). |