الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
 |  | from | 186 |  |  |
| | | from | 186 | | |
Abstract
In the present study, potential protective impact of ginger extract against ciprofloxacin (CPFX)-induced hepato- and cardiotoxicity in male rats was investigated. Forty-two adult male albino rats were divided into seven groups: control, dimethylsulphoxide (DMSO), ginger (200 mg/kg), CPFX20(20 mg/kg), CPFX20plus ginger, CPFX40(40 mg/kg) and CPFX40plus ginger. Both CPFX and ginger doses were orally given to rats for 10 consecutive days. At the end of the experimental period, overnight fasted rats were anesthetized with ketamine/xylazine (10 ml/kg ip) and serum, heart and liver samples were processed for biochemical assays. Obtained results exhibited that treatment of rats with CPFX produced marked increases in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) total bilirubin, creatine kinase MB (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin T (CTnT) . Also, CPFX markedly increased hepatic and cardiac contents of malondialdehyde (MDA), protein carbonyl (PC), hydrogen peroxide (H2O2) and nitric oxide (NO). In addition, the drug induced depletion in the hepatic and cardiac levels of antioxidant parameters including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRd) and glutathione-s-transferase (GST). CPFX was also found to induce apoptosis in the hepatic and cardiac cells as indicated by increased level of p53 and caspase-3 accompanied with decreased level of Bcl-2. The deleterious effects of CPFX on all measured biochemical indices seemed to be dose-dependent. Concurrent treatment with ginger extract and CPFX in rats significantly mitigated the CPFX-induced oxidative stress and apoptosis, and greatly recovered the biomarkers of the liver and heart injury. This study addressed, for the first time, that ginger extract may be useful in the protection against liver and heart damage induced by CPFX. The hepato and cardioprotective impact of ginger might be mediated primarily by its potent antioxidant activity and its ability to scavenge free radicals.