الفهرس 
General introductionOnly 14 pages are availabe for public view
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Abstract
Apocynin (APO) is a bioactive phytochemical possessing a versatile pharmacological effect in treating a wide spectrum of diseases. Nevertheless, it isn’t available in the market as a dosage form. Consequently, the main objective of this thesis was to fabricate different dosage forms for oral and topical delivery of APO that should be beneficial in improving its bioavailability and at the same time conferring patient’s compliance and convenience. One of the main goals of pharmacy and medicine is the delivery of the drugs at the suitable time in a safe manner to a specific target at the therapeutic level. In this study, novel drug delivery systems have been adopted to deliver APO. One approach is the use of nanoparticulate systems that come to the forefront as a viable drug delivery strategy, presenting opportunities for controlled release, protecting active components from enzymatic or environmental degradation and providing specific or targeted drug delivery. The other approach is the film forming system (FFS) which presents a novel platform to deliver drugs to the skin both topical and transdermal. This FFS is simple and offers advantages of transparency, non-greasy, lower skin irritation, wipe off resistance, longer retention, greater increased dosage flexibility, improved patient compliance and aesthetic appearance. The work in this thesis involves the pharmaceutical study on the potential use of polymeric nanoparticle (PNPs) and FFS as promising carriers for enhancing the oral and topical delivery of APO, respectively. Therefore, the efficacy of PNPs and the impact of FFS on the oral and topical delivery of APO, respectively were investigated. To fulfill these goals, this thesis comprises the following two parts: Part I: Novel chitosan oligosaccharide-based nanoparticles for gastric mucosal administration of the phytochemical ”Apocynin”Part II: Novel anti-inflammatory film as a delivery system for the external medication with bioactive phytochemical ”Apocynin”