الفهرس 
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Abstract
This study was planned to diagnose and differentiate the different causes of diarrhea in calves and to evaluate the pharmacological effect of marbofloxacin (2mg/kg BW intramuscularly for three successive days) on hematology, kidney, liver functions and body weight in diarrheic calves with E. coli. The calves under our experiment were determined after long period of survey (from JAN to APRIL 2016) on several dairy farms at Dakahlia and Damietta Governorates, our survey were done on 100 diarrheic calves at different seasons at (0-10) days old age. Our experiment was done on twenty Holstein calves (0-10 days old) in special dairy farm at Damietta Governorate. Calves were divided into two groups, each group ten animals. First group was kept as control group without any drug (controlled healthy calves). The second group include ten diarrheic calves infected with E-coli and was injected by marbofloxacin intramuscularly (2mg/kg B.W) for 3 successive days. Two Blood samples were collected from jugular vein of all calves (the first one for hematological studies and collected in wesserman tube contains anticoagulant and the second sample for serological studies and collected in wesserman tube without anticoagulant) were collected from each experimental animal at zero day, 3rd, 7th, 14th day. Results revealed a significant increase in total leukocytic count, lymphocyte count, monocyte count, eosinophil count, globulin, ALT, AST, ALP, creatinine and urea level. On other hand, results recorded a significant decrease in total erythrocytic count, hemoglobin content, PCV, MCH, MCHC, total protein, Albumin and thrombocyte count in marbofloxacin treated group compared to control one.