الفهرس 
Synchronous fluorescence spectrofluorimetric method for simultaneous determination of amlodipine and metoprololOnly 14 pages are availabe for public view
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Abstract
The thesis is composed of three parts: Part I: General introduction This part presents a general introduction about cardiovascular diseases, their etiology and the current treatment approach. Different classes of cardiovascular drugs and their mechanisms of action are also discussed. Part II: Development and validation of new analytical methods for simultaneous determination of amlodipine and metoprolol
combination
This part consists of three chapters:
Chapter 1: Review of literature This chapter includes an introduction about the chemical and
physicochemical properties of amlodipine and metoprolol and presents
a review of literature about the analytical methods recently reported for
their assay.
Chapter 2: Synchronous fluorescence spectrofluorimetric method for
simultaneous determination of amlodipine and metoprolol
This chapter includes an introduction about the synchronous
fluorescence technique, its types, advantages and applications. This
chapter presents the development and validation of a synchronous
fluorescence spectrofluorimetric method for the simultaneous
determination of amlodipine and metoprolol in their binary mixtures.
The developed method was successfully applied for the
determination of amlodipine and metoprolol in a laboratory prepared
mixture containing all possible excipients present in a tablet dosage form.
This method was published in Luminescence, 33 (2018) 364-369.
Chapter 3: Green micellar HPLC-fluorescence method for
simultaneous determination of metoprolol and amlodipine
This chapter presents an introduction about micellar liquid
chromatographic technique, its advantages and applications. In this
chapter, a green micellar liquid chromatographic method for the
separation and determination of metoprolol and amlodipine was
developed, optimized, validated and successfully applied for the
simultaneous determination of both drugs in their binary mixtures and
combined tablet.
The developed method was further applied for the determination of
metoprolol in spiked human plasma. Assessment of greenness of the
method was also performed. This method was published in
Microchemical Journal, 147 (2019) 635-642
Part III: Development and validation of new analytical methods
for simultaneous determination of atorvastatin and irbesartan
combination
This part is composed of three chapters:
Chapter 1: Review of literature
This chapter includes an introduction about the chemical and
physicochemical properties of atorvastatin and irbesartan and presents
a review of literature about the analytical methods recently reported for
their assay.
Chapter 2: First derivative synchronous fluorescence
spectrofluorimetric method for simultaneous determination of
irbesartan and atorvastatin
This chapter includes an introduction about the advantages of
derivative spectroscopic technique, the combination of synchronous
spectrofluorimetry with derivative technique and its applications. This
chapter describes the development and validation of a first derivative
synchronous fluorescence spectrofluorimetric method for the
simultaneous determination of irbesartan and atorvastatin in their binary
mixtures.
The developed method allowed the determination of irbesartan and
atorvastatin in a laboratory prepared mixture containing all possible excipients present in a tablet dosage form. The developed method was further applied for the determination of irbesartan in spiked human
plasma.
Chapter 3: Green micellar HPLC-fluorescence method for simultaneous determination of irbesartan and atorvastatin In this chapter, a green micellar liquid chromatographic method for
the separation and determination of irbesartan and atorvastatin was
developed, optimized, validated and successfully applied for the
simultaneous determination of both drugs in their binary mixtures and
combined tablet. The developed method was further applied for the determination of irbesartan in spiked human plasma. Assessment of greenness of the method was also performed.