الفهرس 
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Abstract
Preeclampsia is a pregnancy-specific disease clinically defined by new-onset hypertension (> 20 weeks of gestation) with one or more proteinuria and maternal organ dysfunction such as renal insufficiency, liver dysfunction, neurological problems, fetal growth restriction or uteroplacental dysfunction. Preeclampsia remains a major cause of death and serious maternal morbidity. The pathophysiology’s complexity is a challenge for future studies that can assist prevent preeclampsia and minimize complications of the maternal and fetal system.
One of the causes of preeclampsia was suggested to be the connection between placental and vascular ischemia, impaired angiogenesis, vascular inflammation, and endothelial dysfunction. ET 1 is a powerful vasoconstrictor substance that affects the endothelium of the maternal vascular. It is noted that there are enhanced levels of ET 1 in PE resulting in endothelial dysfunction that may be due to TNF alpha rise.
Adropin is a peptide that is closely linked to pro- and anti-angiogenic molecules that lead to endothelial dysfunction and its involvement in PE pathogenesis.
The current study was a prospective observational case control study conducted at the department of Obstetrics and Gynecology, Beni- Suef University Maternity Hospital. This study was done on 50 pregnant women aged from 18 to 35 years old and they were divided into two groups:
1- Preeclampsia group: included 25 women that have been diagnosed complaining of preeclampsia (study group).
2- Control group: included 25 healthy pregnant women (control group).
The aim of the present study is to asses age, SBP, DBP and BMI together with estimation of the serum levels of ET 1, No, adropin, insulin, proinflammatory biomarker (TNF alpha), oxidative stress markers (MDA and SOD), lipid profile (TG, total cholesterol, LDL and HDL) and determine the correlation between ET 1, NO and adropin in normal pregnant women and women with preeclampsia.
The results of the present work showed that the mean values of BMI, serum ET 1, pro-inflammatory biomarker (TNF-alpha), oxidative stress marker (MDA), lipid profile (TG, total cholesterol, LDL) were significantly higher in the pregnant women with preeclampsia than in the healthy control pregnant women.
However, the mean serum values of NO, adropin, insulin, antioxidant biomarker (SOD) were significantly lower and serum HDL was insignificantly lower in the pregnant women with preeclampsia than in the healthy control pregnant women.
Also, The results of the present study showed that there was a significant positive correlation between ET1 and NO. Also, there was a significant positive correlation between NO and insulin. While the correlation between adropin and ET1 was insignificant.