الفهرس 
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Abstract
The current study was carried out to study the impact of Dex on magnetic resonant imaging (MRI) brain scores at term equivalent, neurological examination, and pain scores in mechanically ventilated preterm infants. A total 60 preterm infants (≥32weeks) received mechanical ventilation in NICU in MUCH administered through endotracheal tube during the first 5 days of life -were classified into two groups, 30 neonates in each arm: • group 1 (DEX group): Infants received Dex at loading dose: 0.1 mcg/kg given over 10-20 minutes followed by maintenance dose: 0.1 mcg/kg/hour by infusion over 24 hours. •group 2 (control group): infants received equivalent amount of intravenous saline. There was significant difference observed for being abnormal white matter, moderate abnormality and white matter quantitative in favor of DEX group with no significant difference detected in mild abnormality and sever abnormalit. Also, There was significant difference observed for being abnormal grey matter and quantative grey matter in favor of DEX group. from our study, we concluded that DEX at sedative dosage regimen has good sedative and neuro-protective effects when used in mechanically ventilated preterm infants. Also, The use of DEX is associated with lower incidence of sepsis and NEC when compared to placebo. In addition, the use of DEX is well tolerated with no reported serious side effects