الفهرس | Only 14 pages are availabe for public view |
Abstract The present study was carried out to monitor the synergistic effect of systemic valacyclovir and combination of amoxicillin and metronidazole with open flap debridement on the clinical parameters and subgingival HCMV genomic counts in localized aggressive periodontitis patients using TaqMan real-time PCR. Sixteen localized aggressive periodontitis patients positive for HCMV were selected from the Periodontology Clinic, Faculty of Dentistry, Tanta University. Their ages ranged from 18 to 34 years. Patients were randomly divided into two groups. group I : Eight patients were treated with systemic antibiotic (combination of amoxicillin 250 mg and metronidazole 250 mg three times daily for each) for 10 days. group II : Eight patients were treated with systemic antiviral Valtrex (500 mg of valacyclovir orally three times daily) + systemic antibiotic (combination of amoxicillin 250 mg and metronidazole 250 mg three times daily for each) for 10 days. All patients have received proper oral hygiene instructions and full mouth scaling and root planing under local anesthesia. In addition, occlusal adjustment was performed when indicated. All patients were treated with open flap debridement in addition to systemic medication which started at the same day of the open flap debridement. |