الفهرس | Only 14 pages are availabe for public view |
Abstract Objective: To report data on the feasibility, safety, and effectiveness of activated platelet rich plasma in accelerating the healing rate of non-ischemic DFU. Design: This is a prospective, randomized, controlled, blinded study that will be conducted in Ain Shams university and Sheikh Zayed Specialized hospital vascular surgery unit. Methods: 30 patients with non-ischemic DFU were classified into two groups: group A: Patients with nonischemic DFU and were treated with a novel modality i.e.: PRP injection in the healing edge and the floor of the targeted ulcer. group B: Patients with non-ischemic DFU who had usual standard care i.e.: moist dressing with or without collagenase ointment. All cases had a minimal debridement prior to treatment, Here in our study the demographic data i.e. Age, sex, medical history were homogenously distributed among both groups. All cases in both groups were non ischemic after successful revascularization either by OR or ER. Results: The rate of complete healing for ulcers in group A was achieved in six patients (40%) at the fifth week, while five patients (33.33%) were healed completely by the sixth week and only one patient (6.67%) healed in the ninth week. 26.67 % (n=4 cases) in group B showed complete healing rate by eighth week and 40% (n=6 cases) were healed by ninth week while 33.33% (n=5 cases) were healed in the tenth week. P value was statistically significant <0.001 between the groups. Conclusion: Activated platelet rich plasma is a novel modality in treatment of diabetic foot ulcers which is feasible, save and effective with high rate of limb salvage rate and clinical improvement. |