الفهرس | Only 14 pages are availabe for public view |
Abstract As the average age of people increases, there is a growing demand for materials that enhance the repair and regeneration of the bones. Biomaterial is any substance or blend of substances that can be utilized in general or as a piece of a framework in the human body to improve physiological function and quality of life. Bioactive silicate glasses present great advantages as biomaterials, due to their high bioactivity and their ability to make bonds with both soft and hard tissues. Therefore, silicate bioactive glass has been subjected to extensive research. Properties of bioactive glasses can be modified by addition a small amount of various elements which make the material more compatible for different clinical applications. The main objectives of our study are fabrication a novel silicate bioactive glass and investigation the influence of cerium doping on the prepared bioactive glass then apply the doped bioactive glass in the polymer scaffolds. The thesis consists of three chapters as follow: Chapter one: This chapter contains introduction about bioactive glasses and literature review. Chapter two: This chapter contains two parts, the first part presents the used materials and the research methodology for: synthesis of nanoparticle bioactive glass powder composed of 52 wt. % SiO2, 41 wt. % CaO, 7 wt. % P2O5 via sol –gel method, synthesis of cerium doped nanoparticles bioactive powders which composed of [52 SiO2, (41-x) CaO, 7 P2O5, xCe2O3] with x= 2.0, 4.0, 6.0 and 8.0 in (wt. %), preparation of simulated body fluid and fabrication of porous a 3D composite scaffold from blending of (HEC/PVP) polymer and bioactive glass doped with 8% cerium oxide. The second part of this chapter is devoted for instruments which were used for the characterization of prepared glass samples and scaffolds. Chapter three: This chapter consists of three separate parts; the first is concerned with the results of silicate bioactive glass nanoparticles. Structure and bioactivity of the prepared powder have been investigated using various techniques. Also, the specific surface area and mean pore size of the prepared glass powders have been examined and the second part presents the investigation of doping effect on the prepared nanostructure bioactive glass with different concentrations of cerium oxide. The third part deals with the characterization`s results of the prepared composite scaffolds from blending of (HEC/PVP) polymer and 8% cerium oxide doped bioactive glass nanoparticles. At the end of this chapter, there is a conclusion of the three chapters. |