الفهرس 
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Abstract
Aim of the work: To assess the serum and synovial fluid (SF) profile of IL-17A in primary knee OA patients; and their correlations with functional status and disease severity.
Patients and methods: Thirty five patients with primary knee OA (23 males and 10 females), and fifteen age, sex and BMI matched healthy individuals were included. Western Ontario and Mcmaster University osteoarthritis index (WOMAC), visual analogue scale (VAS), Lequesne index, and Kellgren and Lawrence (KL) grading scale were used for assessment of functional status, pain and disease severity. IL-17A levels were measured in serum (of patients and healthy controls) and SF (of patients) using an enzyme-linked immunosorbent assay (ELISA).
Results: The serum levels of IL-17A were significantly higher in OA patients than controls (P= 0.04). Serum and SF IL-17A levels tended to be higher with the increment of KL grade with statistically significant differences. Significant positive correlation between serum and SF IL-17A levels was found (r= 0.34). Serum and SF IL-17A levels had significant positive correlations with VAS (r= 0.42, r= 0.91 respectively), WOMAC pain score (r= 0.37, r= 0.87 respectively), and Lequesne pain score (r= 0.37, r= 0.91 respectively). Serum and SF IL-17A levels had significantly positive correlations with Lequesne index (r= 0.40, r= 0.87 respectively), while SF IL-17A level not serum had a very strong positive correlation with radiographic severity (KL grade) (r= 0.93). Age of the patients, BMI and serum IL-17A levels were significant predictors of primary knee OA (P= 0.03, P= 0.03, P= 0.04 respectively).
Conclusion: Serum levels of IL-17A were significantly higher in primary knee OA patients than controls. Serum and SF IL-17A levels were significantly higher with the increment of radiographic severity. The correlations of serum and SF IL-17A levels with WOMAC score, Lequesne index and KL grading scale reflecting the role of IL-17A in OA knee pain, functional disability and disease severity.