الفهرس 
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Abstract
Rheumatoid arthritis (RA) is the most commonly diagnosed systemic inflammatory arthritis, with a lifetime prevalence of up to 1 percent worldwide. Onset can occur at any age, but peaks between 30 and 50 years. Disability is common and significant.
The etiology of RA is multifactorial. Genetic susceptibility is evident in familial clustering and monozygotic twin studies, with 50 percent of RA risk attributable to genetic factor.
Women, smokers, and those with a family history of the disease are most often affected. Older age, a family history of the disease, and female sex are associated with increased risk of RA, although the sex differential is less prominent in older patients.