الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Meclizine HCl (MCZ) is commonly used due to fewer adverse effects than other antihistaminic drugs but its onset of action is about 1 h and possesses short half-life (6h). MCZ is a poor water-soluble drug and associated with slow rate of absorption from oral route, therefore, a tablet with a coat and a core with immediate and prolonged drug absorption, respectively, was prepared. We here investigate the physical properties and the release characteristics. In addition, the stability study through thermogravimetric analysis and in-vivo evaluation of the prepared tablets were assessed. A new orodissolvable/ dispersible tablet containing MCZ NPs would augment the dual rapid absorption of the drug from the buccal cavity as well as prolonging that from GIT. In the second part of the thesis, Gadodiamide (GDD) is magnetic resonance imaging (MRI) contrast agent as intravenous solution even for GIT-MRI. Unfortunately, it suffers from high renal toxicity. The aim was to formulate GDD in a core/shell electrospun fibers for intestinal examination and decrease its renal toxicity. Besides, preparation, characterization and in-vitro evaluation of the optimized formula would be investigated. The work was concerned with the formulation of GDD as a small and large intestine targeted coaxial NFs. The formulation consists of electrospun NFs core of GDD. Polyvinylpyrrolidone (PVP K90) and hydroxypropyl-β-cyclodextrin (HP-β-CyD) are the main polymers used to prepare the core of the GDD NFs. Sodium saccharine and glycerol are used. The shell of the NFs is made of Eudragit S 100 (ES 100) which is characterized by its high solubility at pH>7.4 to produce small and large intestine targeted NFs. The optimized formula was further subjected to in-vitro release, as well as ingredient compatibility study. In-vitro cytotoxicity and thermogravimetric analysis were achieved. X-ray imaging was fulfilled to test its radiopacity.