الفهرس | Only 14 pages are availabe for public view |
Abstract Serum ferritin is widely recognized as an acute phase reactant and marker of acute and chronic inflammation, and is non specifically elevated in a wide range of inflammatory conditions, including chronic kidney disease, rheumatoid arthritis and other autoimmune disorders. Marked hyperferritinaemia has often been uniquely ascribed to such rare rheumatological, and may be very specific for them. The pathogenesis of hyperferritinaemia is thought to be cytokine-mediated, with interleukin IL1a, IL1b, IL6, IL18, tumor necrosis factor-a, c-interferon and macrophage-colony stimulating factor all implicated. Hyperferritinemia has been scantly investigated in autoimmune diseases. The rationale for evaluating this protein in autoimmune diseases derives from it being an acute phase reactant (APR), and hence increased during inflammation. |