الفهرس 
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Abstract
Introduction: Patients with liver cirrhosis have been found to be more likely to acquire bacterial infections due to their dysregulated immune function. Infections are present at admission or develop during hospitalization in 25–35% of patients. CRP may be a surrogate marker for the early identification of infection in hospitalized cirrhotic patients. Aim of this study: To evaluate the role of C-reactive protein as a predictor of early bacterial infection in a group of cirrhotic patients admitted to hospital. Patients and methods: The study included 150 subjects admitted to Hepatology and Gastroenterology Unite at Mansoura Speciliazed Medical Hospital from November 2018 to April 2019. Then patients were distributed into 3 groups; group( I ) that included 50 cirrhotic patients with infection, group (II) that included50 cirrhotic patients without infection and group (III) that included 50 patients not cirrhotic with infection (control group). Methods: The cases were subjected to full history taking (including demographic data, history of the current disease and associated chronic disease) and full clinical examination. Laboratory investigations were done including assessment of serum CRP levels. Serum CRP levels were measured using turbidimetric assay. Radiological investigations included abdominal/S and chest X-ray. Results: The mean age and sex distribution of the cases showed no statistically significant difference between the study groups. All the tested laboratory parameters (WBCs count , Platelets , S.Abumin, S.Creatinine, INR , Bilirubin , ALT and AST revealed high level of significance between the different study groups except the hemoglobin. HCV infection in cirrhotic groups did not show significant difference As regard severity of liver cirrhosis, MELD score showed high statistically significant difference between cirrhotic groups .but Child Pugh score did not show significant difference. Source of bacterial infections and body temperature within the infected groups (cirrhotic with infection and control) Show a statistically significant difference. The median level of CRP within the cases of the study groups showed high level of significance .Correlation between CRP levels and source of infection in cirrhotic patients with infection did not show level of significance. Correlation between CRP and WBCs counts showed high level of significance. The cutoff point of CRP to differentiate between cirrhotic cases with infection and cirrhotic without infection was 14.5 mg/L with 100% sensitivity, 94 % specificity and total accuracy of 97%.