الفهرس 
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Abstract
Introduction: Psoriasis is a lifelong, chronic, and immune-mediated systemic disease, it is a complex genetic disorder caused by the interplay of many different genes in addition to environmental factors. Recent clinical and experimental studies have demonstrated that the innate immune system plays a role in the pathogenesis of psoriasis. Psoriatic patients have an increased risk of developing other chronic health diseases such as psoriatic arthritis, metabolic syndrome (MetS), depression, non-alcoholic fatty liver disease, Crohn’s disease, lymphoma and cardiovascular disorders. Salusins belong to a new class of peptides, these bioactive peptides are synthesized in many tissues, and were found in biological fluids such as blood and urine. Salusin Beta may act as a potential proatherogenic factor, salusin Beta were significantly higher in patients with angiographically proven CAD, Salusin Beta stimulates proliferation of VSMCs and vascular fibrosis which closely linked to atherosclerosis . The Aim of this study: This study aims to estimate serum level of salusin beta in patients with psoriasis vulgaris and to assess its correlation with disease severity. Materials and methods: Our study was conducted on 45 patients with psoriasis vulgaris, their ages ranged from 20 to 78 years to be compared with 40 healthy individuals of matched age and sex serving as a control group. Results: This study revealed that the serum levels of salusin Beta in psoriatic patients are significantly elevated compared to control group. There is a highly significant positive correlation between serum salusin Beta levels and severity of disease evaluated by PASI score. There is statistically significant higher of blood glucose, serum cholesterol and LDL in psoriatic patients compared to the control. However, there are statistically lower levels of serum TG and HDL among psoriatic patients in comparison with control group. No statistically significant correlation between sex, age, BMI, blood glucose, cholesterol, TG, HDL, LDL and serum Salusin Beta. In our study and by using ROC curve for diagnosis of accuracy of serum salusin Beta in prediction of psoriasis cases : • We found that cut off point is 115.34. • Test sensitivity is 91.1%. • Test specificity is 77.5% • Test accuracy is 84.7%. Conclusion: The results of this study revealed that serum levels of Salusin Beta were elevated in psoriatic patients. Also, serum levels of Salusin Beta correlated with the PASI score in the psoriatic patients. These findings suggest that Salusin Beta may play a role in the pathogenesis of psoriasis, and Salusin Beta can be used as an indicator for the severity of the disease.