الفهرس 
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Abstract
Chronic kidney failure defined by evidence of kidney damage or reduction in glomerular filtration rate for at least 3 months. It considered a public health problem in either developed or developing countries. chronic kidney disease is associated with a higher incidence of cardiovascular disease, including an increase in all-cause mortality. Plants and their extracts remain as an important source of therapeutic material and they prevent disease. Peanut oil is derived from the peanut (Arachis hypogaea), a legume that is rich in proteins, vitamins, phytochemicals, anti-oxidants, polyphenols, polyunsaturated, and fiber which play a preventive and protective role against cardiovascular and metabolic diseases. Therefore, this study aimed to examine the renoprotective and cardioprotective effects of oral administration of Peanut oil by stomach tube on the adenine-induced chronic renal failure in adult male rats. Adult male Albino rats weighing about (165±10g) were used in the present study. Following an acclimatization period of one week, rats were randomly classified into 4 groups (n=6) as follow : 1) Control (CON): Rats fed on normal diet with no additive for 4 weeks. 2) Peanut oil (PO): Rats fed on standard diet and orally received PO by stomach tube at a dose (0.75 ml/kg) B.wt for 4 weeks. 3) Adenine (AD): Rats fed on normal diet with AD (0.75 % w/w) for 4 weeks. 4) AD + PO: Rats fed adenine containing diet (0.75 % w/w) and orally received PO by stomach tube at a dose (0.75 ml/kg) B.wt for 4 weeks. The obtained results can be summarized as follows: A) In adenine group. • A significant decrease in body weight gain associated with significant increase in absolute and relative kidney weight with a significant increase in relative heart weight. • There was a significant increase in serum creatinine, uric acid and BUN. • A significant increase in urine volume, appearance of urinary protein as well as significantly increased urine NAG concentration, while urinary creatinine, urinary urea nitrogen and creatinine clearance were decreased. • A significant increase in renal and cardiac oxidative stress markers (MDA and XO) and decreased in renal and cardiac antioxidants markers (SOD, CAT, GSH and TAC). • The results showed a significant increase in Serum Total lipid, Total cholesterol, Triglycerides, LDLc and VLDLc but a significant decrease in Serum HDLc. • A significant increase in serum cardiac markers like, cTnI level, CK, CK-MB, LDH and AST concentrations. • Concentrations of inflammatory markers (C-RP, TNF-α, IL-6 and IL-10) were significantly increased. B) In adenine + Peanut oil treated groups : The current study showed that, administered of Peanut oil with adenine suppress the hazardous effect of adenine, where they improved kidney and heart structural and function as it attenuated the changes in kidney function, cardiac markers, renal and cardiac oxidative stress markers and antioxidants markers, lipid profile and inflammatory markers. Accordingly, it is concluded that, Peanut oil may supress renal injury caused by adenine and hence cardiac disease in adult male rats.