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Abstract Toxoplasma gondii is recognized as an important opportunistic pathogen, affects about 25 to 30% of the world’s human population. Toxoplasmosis infection caused by Toxoplasma gondii in healthy individuals is usually asymptomatic and self-limited, leading to chronic infection of tissue that can remain latent, may be for the long life time of the hosts. Toxoplasmosis has long been well-known as an opportunistic infection in immunocompromised patients and has a poor prognosis. It is the third important reason of death in immunocompromised patients after pneumocystis and cryptosporidium. This study was done to assess anti-Toxoplasma gondii IgG and IgM in immunocompromised patients and healthy individuals, to notice the presence of toxoplasmosis in each group and study the relation of gender, age, and type of immunosuppressive diseases in the infection of toxoplasmosis. The result of the study revealed that Toxoplasma gondii IgG and IgM antibodies were more seropositively with immunocompromised patients. This indicates that immunocompromised patients are at a great risk for getting infection with toxoplasmosis , the incidence of getting Toxoplasma gondii infection is not related to the gender or the age but may be related to another reason as the habits or the methods of infection. Regarding to the relation between clinico-pathological diagnosis of the immunocompromised patients and the prevalence of Toxoplasma gondii IgG and IgM antibodies, there were a great risk for getting toxoplasmosis infection with immunocompromised patients in the following order ; the highest risk was found with blood disorder patients receiving steroid therapy followed by solid organ cancer patients, non - Hodgkin’s lymphoma patients, acute lymphoplastic leukemia patients, acute myeloid leukemia patients, Hodgkin’s lymphoma patients, chronic lymphoplastic leukemia, then chronic myeloid leukemia patients. |