الفهرس 
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Abstract
This prospective observational cohort study aimed at evaluating the role played by insulin resistance, lipid metabolism disorder, oxidative stress, resistin, vaspin, Interleukin-18 and asymmetric dimethyl arginine as a marker for endothelial dysfunction in the pathogenesis of preeclampsia. This study involved 20 non-pregnant women (group 1 or control group), 20 normally pregnant women (group 2) and 20 preeclamptic women (group 3) at their third trimester. The pregnant women were assessed at their third trimester and further re-evaluated four weeks after delivery. Preeclamptic women showed more atherogenic lipid profile, significantly higher Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and significantly elevated levels of malondialdehyde, resistin, vaspin and interleukin-18 than the other study groups. The levels of resistin and vaspin showed significant decrease four weeks postpartum in preeclamptic group. We concluded that, preeclampsia was associated with insulin resistance, dyslipidemia, oxidative stress, inflammation and significant changes in adipokines (resistin and vaspin) which focus the attention on the role played by these molecules in the pathogenesis of preeclampsia. Therefore, practitioners should consider regular women’s prenatal clinic visits for monitoring of their blood pressures, asking for regular screening of proteinuria, evaluation of blood glucose, assessment of sFlt-1/ PlGF ratio and evaluation of lipid panel with management of hyperlipidemia. However, our results and recommendations need further looking into by large scale and more longitudinal studies.