الفهرس 
Type 1 Diabetes in Children and AdolescentsOnly 14 pages are availabe for public view
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Abstract
Vascular complications are the major cause of morbidity and mortality in diabetic patients. These result from interactions between systemic metabolic abnormalities, such as hyperglycemia, dyslipidemia, genetic and epigenetic modulators, and local tissue responses to toxic metabolites.
Aim of the work: To assess the role of PTX3 as an early marker of vascular complications in children and adolescents with type 1 diabetes mellitus and its correlation with metabolic control and role of hs-CRP at same cases.
Patients and Methods: This cross sectional Observational Case-Control study was carried out on adolescents with type 1 diabetes mellitus attending the Pediatric and adolescents Diabetes specialized unit (PADU), Pediatric Hospital, Ain Shams University. Patients with type 1 diabetes were defined according to the criteria of International Society of Pediatric and Adolescent Diabetes. An informed consent was obtained from patients, controls or their legal guardians before enrollment in the study.
Results: As regard correlation of serum PTXs-3 with studied parameters we found that there was significant positive correlation between serum PTXs-3 and level of HbA1c, level of TG, level of Total Chloesterol. Additionally, Pentx3 and Hs-CRP levels were elevated in patients with elevated lipid profile (TG&Cholesterol) in comparison with those with normal lipid profile. In the current study no significant difference was found between patients and control groups as regard CIMT, so this marker could be used even before development of macrovascular complications
Conclusion: T1DM leads to increased CIMT, damage to vascular endothelium, and expression of adhesion molecules that increase the risk of atherosclerosis and the mortality due to cardiovascular complications in these patients. The levels of PTX3 and hsCRP were increased in the patients even before increase of CIMT.