الفهرس 
P ANCREATIC C YSTSOnly 14 pages are availabe for public view
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Abstract
Background: Pancreatic cystic lesions (PCLs) may be accidentally discovered in up to 13.5% of cases. These PCLs are of multiple types, including mucinous cysts (intra-ductal papillary mucinous neoplasms [IPMN] and mucinous cystic neoplasms [MCN]) that have a risk of malignant transformation. The difficulty in differentiation between the various PCLs and their unpredictable risk of malignant transformation makes their management difficult. The new diagnostic tools of PCLs often include endoscopic ultrasound guided fine needle aspiration (EUS-FNA) for pancreatic cyst fluid analysis. This paper aims to determine if cystic fluid IL-1β can predict the risk of malignancy and the degrees of dysplasia of pancreatic cysts.
Results: cyst fluid IL-1 β can differentiate between benign and malignant cysts at cutoff value >150 pg/ml; the sensitivity and specificity were 84.00% and 56.00% respectively and also can differentiate between mucinous and non- mucinous pancreatic cysts at cutoff value >150 pg/ml; the sensitivity and specificity were 83.33% and 53.78% respectively, but cannot differentiate between degrees of dysplasia of IPMN.
Conclusions: our study suggests that pancreatic cyst fluid IL-1β can differentiate between mucinous and non-mucinous pancreatic cysts and between benign and malignant pancreatic cysts.